Endocrine Abstracts

Prostate cancer (PCa) is one of the most common causes of cancer-related deaths in men worldwide. Therefore, more specific and non-invasive diagnostic biomarkers as well as novel therapeutic targets are urgently needed. As miRNAs have been proposed as promising elements for the identification of novel diagnostic and therapeutic tools for different pathologies, including cancer, we investigated the miRNA landscape in PCa and explored their putative diagnostic/therapeutic utilit...

Obesity is emerging as a prevalent cause of chronic liver damage, which can lead to the development of metabolic-associated fatty liver disease (MAFLD), nonalcoholic steatohepatitis (NASH), or even hepatocellular carcinoma (HCC). Increasing evidence suggests a profound dysregulation of the splicing machinery (spliceosome and splicing factors) in these pathologies; however, the role of PRPF8, a pivotal spliceosome element, has not been described in chronic liver pathologies. Th...